Dr Tamás Korcsmáros
WebsiteGut Health and Food Safety Programme
I study systems regulation of autophagy in humans. Autophagy is a membrane trafficking pathway that generates autophagosomes which deliver cytosol to lysosomes for degradation. Autophagy provides a powerful means of removing intracellular pathogens and is an important arm of innate immunity to infection.
In the gut, host-pathogen interaction is important for intestinal homeostasis; malfunction of autophagy is related to inflammatory bowel disease (IBD) and cancer progression. A better understanding of the effect of particular bacterial species on the regulation of human intestinal autophagy could help to identify prognosis markers for IBD and colon cancer.
By applying network methodologies my research aims to investigate how foodborne pathogens or probiotics affect autophagy, and how antibiotics treatments could influence intestinal autophagic activity by changing the gut microbiota.
Integrative biology : quantitative biosciences from nano to macro 2017 pIntegr. Biol., 2017, Advance Article
Publisher’s version: 10.1039/c6ib00215c
Identification of critical paralog groups with indispensable roles in the regulation of signaling flow.
Scientific reports 6 p38588
Publisher’s version: 10.1038/srep38588
Intracellular and intercellular signaling networks in cancer initiation, development and precision anti-cancer therapy: RAS acts as contextual signaling hub.
Seminars in Cell & Developmental Biology doi:10.1016/j.semcdb.2016.07.005 pdoi:10.1016/j.semcdb.2016.07.005
Publisher’s version: 10.1016/j.semcdb.2016.07.005
Zebrafish doi:10.1089/zeb.2016.1277. pdoi:10.1089/zeb.2016.1277.
Publisher’s version: 10.1089/zeb.2016.1277
Seminars in Cell & Developmental Biology doi:10.1016/j.semcdb.2016.04.001 pdoi:10.1016/j.semcdb.2016.04.001
Publisher’s version: 10.1016/j.semcdb.2016.04.001
Computational biologists have looked at the complex networks of interacting proteins that drive cancer formation, and found that targeting the neighbours of cancer-causing proteins may be just as effective as focusing on the cancer proteins themselves.more +
A network analysis of proteins that are most important in responding to environmental signals highlights potential targets for drugs and provides better information on the genetic basis of diseases.more +
Published in Nature Methods, the Omnipath data resource and Pypath software offer an unprecedentedly clear view on signalling pathways in living systemsmore +
The third edition of “Guidelines for the use and interpretation of assays for monitoring autophagy” was recently published , featuring the Autophagy Regulatory Network resource and co-authored by Dr Tamas Korcsmarosmore +
A Norwich Research Park translational grant will help in the development of a multi-functional data integration software tool to improve metadata and network analysis efficiencymore +